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KMID : 0355820200410010055
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Korean Journal of Oral Anatomy
2020 Volume.41 No. 1 p.55 ~ p.64
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Systemic injection of Porphyromonas gingivalis lipopolysaccharide induces inflammation in the mouse brain
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Jung Bo-Hyun
Lee Hee-Su
Yoo Ki-Yeon
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Abstract
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Porphyromonas gingivalis is a Gram-negative bacterium that causes periodontal disease in the oral cavity. The possibility that P. gingivalis lipopolysaccharide (PG-LPS) can pass through the blood?brain barrier has been restored; however, it is not known whether it leads to neuroinflammation in the brain. Therefore, in this study, we tried to determine if PG-LPS affects the brain. In this study, inflammatory changes in brain tissues were confirmed through immunohistochemistry 12 h and 24 h after PG-LPS administration. In result, inflammation and cytokine expression were observed in the brain of PG-LPS-administered mice. These results suggest that P. gingivalis can influence inflammation in the brain.
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KEYWORD
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Porphyromonas gingivalis, Lipopolysaccharide, Brain, Inflammation, Cytokine
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